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(-)-Epigallocatechin Gallate

(-)-Epigallocatechin Gallate (EGCG) 是茶类黄酮，具有强大的抗氧化，抗炎和抗癌作用。它可抑制EGFR 信号传导，有抗癌作用。它是谷氨酸脱氢酶 1/2 抑制剂。它通过激活细胞色素c 氧化酶来诱导氧化磷酸化。

CAS号

989-51-5

分子式

C22H18O11

主要靶点

HIV Protease|Reactive Oxygen Species|Ferroptosis|Autophagy|Mitochondrial Metabolism|Endogenous Metabolite

仅限科研使用

Cat No : CM01131

Print datasheet

Synonyms

Epigallocatechol Gallate|(-)-表没食子儿茶素没食子酸酯|EGCG

验证数据展示

  • CAS No.: 989-51-5

    (-)-Epigallocatechin Gallate
    CAS#: 989-51-5

产品信息

Epigallocatechol Gallate(EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. EGCG is a phenolic antioxidant found in a number of plants such as green and black tea. It inhibits cellular oxidation and prevents free radical damage to cells.

CAS号 989-51-5
分子式 C22H18O11
主要靶点 HIV Protease|Reactive Oxygen Species|Ferroptosis|Autophagy|Mitochondrial Metabolism|Endogenous Metabolite
主要通路 凋亡|NF-κB信号通路|免疫与炎症|自噬|代谢|微生物学|蛋白酶体
分子量 458.38
纯度 98.08%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Epigallocatechol Gallate|(-)-表没食子儿茶素没食子酸酯|EGCG

体内活性

Epigallocatechol Gallate (5 and 20 mg/kg, p.o.) inhibits the growth of tumor in the subcutaneous orthotopic transplant model[4].

溶解度

Ethanol:45.8 mg/mL (100 mM),H2O:4.6 mg/mL (10 mM)

细胞实验

LoVo, SW480, HCT-8, and HT-29 cells are seeded in 96-well plates at a concentration of 5×103?cells; each cell line is totally seeded in the 12 wells. Complete medium is added to the wells, up to 200 μL; the medium contains 0 μg/mL, 10 μg/mL, 20 μg/mL, and 35 μg/mL of epigallocatechol gallate. The inhibition rate=[1 - (absorbance of Epigallocatechol Gallate group - absorbance of control group)/(absorbance of control group - absorbance of blank control group)] × 100.

参考文献

1.Khan N, et al. Cancer Res, 2006, 66(5), 2500-2505.
2.Pae M, et al. Food Funct, 2013, 4(9), 1287-1303.
3.Steinmann J, et al. Br J Pharmacol. 2013 Mar;168(5):1059-1073.
4.Jin H, et al. Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling. Onco Targets Ther. 2013;6:145-53.
5.Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system[J]. Chemistry & Biodiversity. 2021
6.Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT[J]. Oncology Reports. 2021, 45(4): 1-1.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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