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(-)-α-Pinene

(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) 是一种单萜类化合物，通过延长 GABAergic 突触传递、作为 GABAA-BZD 受体的部分调节剂并直接与 GABAA 受体的 BZD 结合位点结合来增强 NREMS 的数量而不影响 NREMS 的强度。

CAS号

7785-26-4

分子式

C10H16

主要靶点

Endogenous Metabolite|Antibacterial|Virus Protease|GABA Receptor

仅限科研使用

Cat No : CM08029

Print datasheet

Synonyms

左旋-α-蒎烯|左旋-alpha-蒎烯|(1S)-(-)-Alpha-Pinene

验证数据展示

  • CAS No.: 7785-26-4

    (-)-α-Pinene
    CAS#: 7785-26-4

产品信息

(1S)-(-)-Alpha-Pinene enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directly binding to the BZD binding site of GABAA receptor.

CAS号 7785-26-4
分子式 C10H16
主要靶点 Endogenous Metabolite|Antibacterial|Virus Protease|GABA Receptor
主要通路 代谢|离子通道|神经科学|微生物学
分子量 136.23
纯度 98.02%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 左旋-α-蒎烯|左旋-alpha-蒎烯|(1S)-(-)-Alpha-Pinene

体外活性

(1S)-(-)-Alpha-Pinene significantly increased the duration of non-rapid eye movement sleep (NREMS) and reduced the sleep latency by oral administration without affecting duration of rapid eye movement sleep and delta activity. (1S)-(-)-Alpha-Pinene potentiated the GABAA receptor-mediated synaptic response by increasing the decay time constant of sIPSCs in hippocampal CA1 pyramidal neurons[1]. These effects of (1S)-(-)-Alpha-Pinene on sleep and inhibitory synaptic response were mimicked by zolpidem, acting as a modulator for GABAA-BZD receptors, and fully antagonized by flumazenil, an antagonist for GABAA-BZD receptor. (1S)-(-)-Alpha-Pinene was found to bind to aromatic residues of α1- and -γ2 subunits of GABAA-BZD receptors in the molecular model[1].

溶解度

DMSO:50 mg/mL (367.03 mM),Sonification is recommended.

参考文献

1.Yang H, et al. α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors. Mol Pharmacol. 2016 Nov;90(5):530-539. 2.Kamaitytė-Bukelskienė L, Ložienė K, Labokas J. Dynamics of Isomeric and Enantiomeric Fractions of Pinene in Essential Oil of Picea abies Annual Needles during Growing Season. Molecules. 2021 Apr 8;26(8):2138. 3.Haselton AT, et al. Repellency of α-pinene against the house fly, Musca domestica. Phytochemistry. 2015 Sep;117:469-475.

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