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(R)-(-)-Ibuprofen

(R)-(-)-Ibuprofen ((R)-Ibuprofen) 是 Ibuprofen 的 R 型异构体，对 COX 无作用，可以抑制 NF-κB 的活化；(R)-(-)-Ibuprofen 具有抗炎作用，可用于缓解疼痛的研究。

CAS号

51146-57-7

分子式

C13H18O2

主要靶点

NF-κB

仅限科研使用

Cat No : CM01143

Print datasheet

Synonyms

levibuprofen|(R)-Ibuprofen

验证数据展示

  • CAS No.: 51146-57-7

    (R)-(-)-Ibuprofen
    CAS#: 51146-57-7

产品信息

(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen and inhibits NF-κB activation. (R)-(-)-Ibuprofen has anti-inflammatory and antinociceptive effects.

CAS号 51146-57-7
分子式 C13H18O2
主要靶点 NF-κB
主要通路 NF-κB信号通路
分子量 206.28
纯度 99.47%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 levibuprofen|(R)-Ibuprofen

体外活性

(R)-(-)-Ibuprofen is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity (IC50: 121.8 μM), weaker than that of S(+)-ibuprofen (IC50, 61.7 μM). (R)-(-)-Ibuprofen (1 μM) significantly decreases NF-κB activation and fully prevents NF-κB induction at 10 μM. Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF [1][2].

溶解度

DMSO:45 mg/mL (218.15 mM)

参考文献

1.Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.
2.Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123(4):645-52.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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