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(S)-(-)-Bay-K-8644

(S)-(-)-Bay-K-8644 ((S)-(-)-Bay K 8644) 是 L 型 Ca2+ 通道的激动剂，可激活 Ba2+ 电流，其EC50 为 32 nM。

CAS号

98625-26-4

分子式

C16H15F3N2O4

主要靶点

Calcium Channel

仅限科研使用

Cat No : CM03219

Print datasheet

Synonyms

(S)-(-)-Bay K 8644

验证数据展示

  • CAS No.: 98625-26-4

    (S)-(-)-Bay-K-8644
    CAS#: 98625-26-4

产品信息

(S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel and activates Ba2+ currents with an EC50 of 32 nM.

CAS号 98625-26-4
分子式 C16H15F3N2O4
主要靶点 Calcium Channel
主要通路 离子通道|代谢
分子量 356.3
纯度 98.28%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 (S)-(-)-Bay K 8644

靶点活性

Ba2+ currents:32 nM (EC50)

体外活性

The Ca2+ channel activity is enhanced by 3–30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca2+ channels [1]. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC50: 14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176 [2]. (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum [3].

溶解度

H2O:< 0.1 mg/mL (insoluble) ,ultrasonic warming heat to 60°C,DMSO:120 mg/mL (336.79 mM),Sonification is recommended.

参考文献

1.Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15.
2.Rampe D, et al. Functional interactions between two Ca2+ channel activators, (S)-Bay K 8644 and FPL 64176, in smooth muscle. Mol Pharmacol. 1992 Apr;41(4):599-602.
3.Mironov SL, et al. L-type Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia. J Physiol. 1998 Oct 1;512 ( Pt 1):75-87.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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