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1-HEXACOSANOL

1-HEXACOSANOL 激活 AMPK 和肝脏自噬并抑制 SREBP2，导致降胆固醇活性和肝脏脂肪变性的改善。

CAS号

506-52-5

分子式

C26H54O

主要靶点

AMPK|NPC1L1

仅限科研使用

Cat No : CM12717

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Synonyms

验证数据展示

  • CAS No.: 506-52-5

    1-HEXACOSANOL
    CAS#: 506-52-5

产品信息

Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.

CAS号 506-52-5
分子式 C26H54O
主要靶点 AMPK|NPC1L1
主要通路 PI3K/Akt/mTOR信号通路|表观遗传|离子通道
分子量 382.71
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体内活性

Plasma, hepatic cholesterol concentrations and hepatic steatosis were significantly reduced in high-fat-fed mice orally administered with hexacosanol (0.7 mg/kg body weight/day) for 8 weeks compared to those of vehicle-fed control mice (-15 and -40%, respectively)[1]. Diabetes was induced in 8-week-old male Sprague-Dawley rats by administering an intraperitoneal injection of streptozotocin (50 mg/kg). The rats were divided into four groups and maintained for 8 weeks: control rats, diabetic rats without treatment with N-hexacosanol, and diabetic rats treated with N-hexacosanol (2 mg/kg and 8 mg/kg i.p. every day). Although N-hexacosanol failed to modify the diabetic status, increases in serum creatinine as well as in kidney weight were significantly reduced. The malonaldehyde and transforming growth factor beta-1 (TGF-beta1) concentrations as well as the protein kinase C (PKC) activities in the diabetic kidney were significantly higher than those of the control, which were decreased by treatment with N-hexacosanol. Histological examinations revealed that N-hexacosanol significantly ameliorated diabetic-induced tubulointerstitial pathological changes[2].

溶解度

DMSO:Insoluble

参考文献

1.Lee JH, Jia Y, Thach TT, Han Y, Kim B, Wu C, Kim Y, Seo WD, Lee SJ. Hexacosanol reduces plasma and hepatic cholesterol by activation of AMP-activated protein kinase and suppression of sterol regulatory element-binding protein-2 in HepG2 and C57BL/6J mice. Nutr Res. 2017 Jul;43:89-99. 2.Saito M, Kinoshita Y, Satoh I, Shinbori C, Kono T, Hanada T, Uemasu J, Suzuki H, Yamada M, Satoh K. N-hexacosanol ameliorates streptozotocin-induced diabetic rat nephropathy. Eur J Pharmacol. 2006 Aug 21;544(1-3):132-7.

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