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10074-A4

10074-A4 是与 c-Myc370-409 结合的 c-Myc 结合化合物，具有抗癌作用，其行为类似于“蛋白质云”周围的“配体云”，具有与非结合配体不同的特征。

CAS号

312631-87-1

分子式

C18H14Cl2N2O3S

主要靶点

c-Myc

仅限科研使用

Cat No : CM09204

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Synonyms

验证数据展示

  • CAS No.: 312631-87-1

    10074-A4
    CAS#: 312631-87-1

产品信息

10074-A4 is a c-Myc binding compound that associates with c-Myc370–409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features from that of a non-binding ligand.

CAS号 312631-87-1
分子式 C18H14Cl2N2O3S
主要靶点 c-Myc
主要通路 细胞周期
分子量 409.29
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

c-Myc:15.1 ± 2.3 μM(EC50)|c-Myc:36.3 ± 9.0 μM(Kd)

体外活性

10074-A4 showed binding affinity with c-Myc370–409 with Kd of 36.3?±?9.0?μM and EC50 of 15.1?±?2.3?μM[2].10074-A4 arrests the cell cycle at the S-phase in a dose-dependent manner in HL-60 cells[2].

溶解度

DMSO:100 mg/mL (244.33 mM)

参考文献

1.Fan Jin, et al. Ligand clouds around protein clouds: a scenario of ligand binding with intrinsically disordered proteins. PLoS Comput Biol. 2013;9(10):e1003249.
2.Chen Yu, et al. Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc. Sci Rep. 2016 Mar 2;6:22298.

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