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18α-Glycyrrhetinic acid

18α-Glycyrrhetinic acid (Enoxolone) 是一种饮食衍生的化合物，是 NF-kB 的抑制剂和蛋白酶体的激活剂，在多细胞生物中起到促进长寿和抗聚集因子的作用。它诱导细胞凋亡。

CAS号

1449-05-4

分子式

C30H46O4

主要靶点

Proteasome|Apoptosis|NF-κB

仅限科研使用

Cat No : CM12127

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Synonyms

Enoxolone|18-α-甘草次酸|甘草次酸|Glycyrrhetinic acid

验证数据展示

  • CAS No.: 1449-05-4

    18α-Glycyrrhetinic acid
    CAS#: 1449-05-4

产品信息

18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb licorice. It is used in flavoring and it masks the bitter taste of drugs like aloe and quinine. It is effective in the treatment of peptic ulcer and also has expectorant (antitussive) properties.

CAS号 1449-05-4
分子式 C30H46O4
主要靶点 Proteasome|Apoptosis|NF-κB
主要通路 NF-κB信号通路|蛋白酶体|凋亡|泛素化
分子量 470.68
纯度 99.83%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Enoxolone|18-α-甘草次酸|甘草次酸|Glycyrrhetinic acid

溶解度

DMSO:4.71 mg/mL (10 mM),Sonification is recommended.

参考文献

1.Parida PK, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3865-8.
2.Huang S, Cao B, Zhang J, et al. Induction of ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B: molecular mechanism and therapeutic potential[J]. Cell Death & Disease . 2021, 12(3): 1-13.

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