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3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide

3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide inhibits multidrug resistance protein (MRP1).

CAS号

246238-55-1

分子式

C28H24ClN3O6

主要靶点

MRP

仅限科研使用

Cat No : CM08389

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Synonyms

验证数据展示

  • CAS No.: 246238-55-1

    3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide
    CAS#: 246238-55-1

产品信息

3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide 可抑制multidrug resistance protein (MRP1)。

CAS号 246238-55-1
分子式 C28H24ClN3O6
主要靶点 MRP
主要通路 免疫与炎症
分子量 533.96
纯度 99.62%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体外活性

LY402913 demonstrated reversal of MRP1-mediated drug resistance (in the presence of a sublethal dose of doxorubicin) in the MRP1-transfected cell line, HeLa-T5, EC50 = 0.90[1].

溶解度

DMSO:55 mg/mL (103 mM)

参考文献

1.Norman BH, Lander PA, Gruber JM, Kroin JS, Cohen JD, Jungheim LN, Starling JJ, Law KL, Self TD, Tabas LB, Williams DC, Paul DC, Dantzig AH. Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1). Bioorg Med Chem Lett. 2005 Dec 15;15(24):5526-30. doi: 10.1016/j.bmcl.2005.08.075. Epub 2005 Oct 3. PMID: 16202586.

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