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4'-Hydroxy-2,4-dimethoxychalcone

4'-Hydroxy-2,4-dimethoxychalcone 是红色龙血天竺葵草药树脂中的天然查尔酮衍生物。4'-Hydroxy-2,4-dimethoxychalcone 具有广泛的生物学活性，包括抗疟疾，抗细菌，抗真菌和抗原生动物活性。

CAS号

151135-64-7

分子式

C17H16O4

主要靶点

Antibacterial|Antifungal|Parasite

仅限科研使用

Cat No : CM13135

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Synonyms

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  • CAS No.: 151135-64-7

    4'-Hydroxy-2,4-dimethoxychalcone
    CAS#: 151135-64-7

产品信息

4'-Hydroxy-2,4-dimethoxychalcone is a naturally occurring chalcone derivative from the herbal resin of the red geranium Dragon's Blood.4'-Hydroxy-2,4-dimethoxychalcone possesses a wide range of biological activities including anti-malarial, anti-bacterial, anti-fungal, and anti-protozoa activity.

CAS号 151135-64-7
分子式 C17H16O4
主要靶点 Antibacterial|Antifungal|Parasite
主要通路 微生物学
分子量 284.31
纯度 98.31%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体内活性

4'-Hydroxy-2,4-dimethoxychalcone (compound 2) (160 mg/kg; oral; ICR mice) has a T1/2=1.94 hours, Cmax=158 ng/mL, and AUC=384 ng•h/mL.[1]

体外活性

4'-Hydroxy-2,4-dimethoxychalcone (compound 2) is against P.falciparum D6 and W2 with IC50 was 4.2 μM and 4.8 μM, respectively.[1]

参考文献

1.Gutteridge CE, et al. In vitro biotransformation, in vivo efficacy and pharmacokinetics of antimalarial chalcones. Pharmacology. 2011;87(1-2):96-104.
2.Qing-An Zheng, et al. Flavonoids from the Resin of Dracaena cochinchinensis. Helvetica Chimica Acta, 87(5), 1167–1171.

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