Na 4-Hydroxynonenal Monoclonal antibody, PBS Only

4-Hydroxynonenal Monoclonal Antibody for ELISA, Indirect ELISA
Cat No. 68538-1-PBS

产品说明书

CloneNo. 2C1D10

宿主/亚型

Mouse / IgG2a

种属反应性

4-hydroxynonenal, chemical compound

应用

ELISA, Indirect ELISA

Cas. 75899-68-2, C9H16O2, 4-Hydroxy-2-nonenal, 4-HNE

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


产品信息

68538-1-PBS targets 4-Hydroxynonenal in ELISA, Indirect ELISA applications and shows reactivity with 4-hydroxynonenal, chemical compound samples.

经测试应用 ELISA, Indirect ELISA Application Description
经测试反应性 4-hydroxynonenal, chemical compound
免疫原 PTG 种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 4-Hydroxynonenal
别名 Cas. 75899-68-2, C9H16O2, 4-Hydroxy-2-nonenal, 4-HNE
基因名称
Gene ID (NCBI)
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

4-Hydroxynonenal is a uremic toxin. Uremic toxins can be subdivided into three major groups based upon their chemical and physical characteristics: 1) small, water-soluble, non-protein-bound compounds, such as urea; 2) small, lipid-soluble and/or protein-bound compounds, such as the phenols and 3) larger so-called middle-molecules, such as beta2-microglobulin. 4-Hydroxynonenal (4-HNE) is a major aldehydic product of ω-6-unsaturated fatty acid peroxidation. It is considered a lipid peroxidation specific marker. 4-HNE has been found to induce differentiation and inhibit proliferation of HL-60 human leukemic cells. It has also been found to induce murine alveolar macrophage cell death. 4-HNE has been shown to inhibit State 3 respiration, causing a transient cytosolic Ca2+ increase. In addition, it irreversibly inhibits Na+-K+-ATPase activity.

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