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4-MMPB

4-MMPB (15-Lipoxygenase Inhibitor 1) 是一种选择性15-脂氧合酶抑制剂，其 IC50值为 18 μM，具有前列腺癌的研究潜力。它对大豆 15-脂氧合酶和人 15-脂氧合酶-1 的 IC50 分别为 19.5 μM 和 19.1 μM。

CAS号

928853-86-5

分子式

C16H19N5S

主要靶点

Apoptosis|Lipoxygenase|Others

仅限科研使用

Cat No : CM09154

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Synonyms

15-Lipoxygenase Inhibitor 1

验证数据展示

  • CAS No.: 928853-86-5

    4-MMPB
    CAS#: 928853-86-5

产品信息

15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer.

CAS号 928853-86-5
分子式 C16H19N5S
主要靶点 Apoptosis|Lipoxygenase|Others
主要通路 其他|代谢|凋亡
分子量 313.4
纯度 98.75%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 15-Lipoxygenase Inhibitor 1

靶点活性

Others:69.6 μM

体外活性

15-Lipoxygenase Inhibitor 1 has an IC50 of 69.6 μM for DPPH bleaching；15-Lipoxygenase Inhibitor 1 (41.48 μM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells[1][2].

溶解度

DMSO:8mg/mL (25.52mM)

参考文献

1.Nikpour M , Mousavian M , Mahdieh Davoodnejad…. Synthesis of new series of pyrimido[4,5- b ][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism[J]. Medicinal Chemistry Research, 2013, 22(10):5036-5043. 2.Saboormaleki S , Sadeghian H , Bahrami A R , et al. 7-Farnesyloxycoumarin Exerts Anti-cancer Effects on a Prostate Cancer Cell Line by 15-LOX-1 Inhibition[J]. Archives of Iranian Medicine, 2018, 21(6):251-259. 3.Alavi S J , Sadeghian H , Seyedi S M , et al. A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarin[J]. Chemical Biology & Drug Design, 2018.

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