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4-Oxofenretinide

4-Oxofenretinide (3-Keto fenretinide) 是一种最近发现的 fenretinide 代谢物，可诱导显着的 G2-M 细胞周期停滞和细胞凋亡。

CAS号

865536-65-8

分子式

C26H31NO3

主要靶点

cell cycle arrest

仅限科研使用

Cat No : CM20541

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Synonyms

4-氧代维甲酰酚胺|3-Keto fenretinide

验证数据展示

  • CAS No.: 865536-65-8

    4-Oxofenretinide
    CAS#: 865536-65-8

产品信息

4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis.

CAS号 865536-65-8
分子式 C26H31NO3
主要靶点 cell cycle arrest
主要通路 细胞周期
分子量 405.53
纯度 96.89%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 4-氧代维甲酰酚胺|3-Keto fenretinide

溶解度

DMSO:50 mg/mL (123.29 mM)

参考文献

1.Villani MG,et al.4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47.
2.Appierto V,et al.Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity. Mol Cancer Ther. 2009 Dec;8(12):3360-8.
3.Villani MG,et al.Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1. Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6265-75.

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