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5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole

Antileishmanial agent-2 是一种基于 3-Br-isoxazoline 的疟原虫抑制剂恶性疟原虫（D10 和 W2 菌株）和利什曼原虫属。 (L. infantum 和 L.tropica) 前鞭毛体，IC50 为 0.035、0.058、3.5 和 7.5 μM。

CAS号

2863687-18-5

分子式

C15H16BrN3O2

主要靶点

Parasite

仅限科研使用

Cat No : CM10203

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Synonyms

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  • CAS No.: 2863687-18-5

    5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole
    CAS#: 2863687-18-5

产品信息

5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole is a 3-Br-isoxazoline-Based Inhibitors against Plasmodium falciparum (D10 and W2 strains) and Leishmania spp. (L. infantum and L. tropica) Promastigotes with IC50s of 0.035, 0.058, 3.5 and 7.5 μM.

CAS号 2863687-18-5
分子式 C15H16BrN3O2
主要靶点 Parasite
主要通路 微生物学
分子量 350.21
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

P. falciparum:35 nM(D10 strains)|P. falciparum:58 nM(W2 strains)

溶解度

DMSO:65 mg/mL (185.6 mM)

参考文献

1.Galbiati A, et al. Development of Potent 3-Br-isoxazoline-Based Antimalarial and Antileishmanial Compounds. ACS Med Chem Lett. 2021 Oct 13;12(11):1726-1732.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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