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[6]-Gingerol

[6]-Gingerol ((S)-(+)-[6]Gingerol) 是一种从生姜中分离的活性物质，具有抗癌，抗炎和抗氧化活性。

CAS号

23513-14-6

分子式

C17H26O4

主要靶点

AMPK|Apoptosis

仅限科研使用

Cat No : CM00629

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Synonyms

6-姜酚|(S)-(+)-[6]Gingerol|gingerol|6-Gingerol

验证数据展示

  • CAS No.: 23513-14-6

    [6]-Gingerol
    CAS#: 23513-14-6

产品信息

[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues.

CAS号 23513-14-6
分子式 C17H26O4
主要靶点 AMPK|Apoptosis
主要通路 表观遗传|凋亡|PI3K/Akt/mTOR信号通路
分子量 294.4
纯度 99.59%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 6-姜酚|(S)-(+)-[6]Gingerol|gingerol|6-Gingerol

体内活性

In animal studies, [6]-gingerol significantly ameliorates DSS-induced colitis by restoration of body weight loss, reduction in intestinal bleeding, and prevention of colon length shortening. Besides, [6]-gingerol suppresses DSS-elevated production of proinflammatory cytokines (IL-1β, TNFα, and IL-12)[2].

体外活性

[6]-gingerol inhibits colon cancer cell proliferation and induced apoptosis without affecting the normal colon cells. [6]-gingerol down-regulates phorbol myristate acetate induced phosphorylation of ERK1/2 and JNK MAP kinases and activation of AP-1 transcription factor, but has only little effects on phosphorylation of p38 MAP kinase and activation of NF-kappa B[1]. [6]-gingerol treatment is shown to restore impaired intestinal barrier function and to suppress proinflammatory responses in DSS-treated Caco-2 monolayers. AMPK is activated on [6]-gingerol treatment[2]. Treatment with [6]-gingerol results in a significant decrease in the viability of osteosarcoma cells in a dose-dependent fashion. In parallel, the number of cells arrested at the sub-G1 cell cycle phase is significantly increased. [6]-gingerol induces activation of caspase cascades and regulates cellular levels of Bcl2 and Bax[3].

溶解度

DMSO:53 mg/mL(180 mM),Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble

细胞实验

[6]-gingerol stock (20 mg/mL) is prepared in ethanol and the working concentrations are prepared by diluting this stock in dimethyl sufoxide (DMSO). For MTT assay, 5×103 cells/well of human colon cancer cells and 104 cells/well of mouse IECs are seeded in 96-well plates. Cells are treated with [6]-gingerol for 48 h,72 h or 96 h before performing MTT assay and for 16 h before Annexin-V staining[1].

参考文献

1.Radhakrishnan EK, et al. [6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling. PLoS One. 2014 Aug 26;9(8):e104401.
2.Chang KW, et al. 6-Gingerol modulates proinflammatory responses in dextran sodium sulfate (DSS)-treated Caco-2 cells and experimental colitis in mice through adenosine monophosphate-activated protein kinase (AMPK) activation. Food Funct. 2015 Oct;6(10):3334-41.
3.Fan J, et al. 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation. Tumour Biol. 2015 Feb;36(2):1135-41.

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