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ABC99

ABC99是 wnt 脱酰基酶的一种选择性不可逆抑制剂。ABC99抑制 NOTUM（IC50:13 nM）。它还显示了对丝氨酸水解酶家族的优良选择性。

CAS号

2331255-53-7

分子式

C22H21ClN4O5

主要靶点

Wnt/beta-catenin

仅限科研使用

Cat No : CM19771

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Synonyms

ABC 99|ABC-99

验证数据展示

  • CAS No.: 2331255-53-7

    ABC99
    CAS#: 2331255-53-7

产品信息

ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family.

CAS号 2331255-53-7
分子式 C22H21ClN4O5
主要靶点 Wnt/beta-catenin
主要通路 干细胞|细胞骨架
分子量 456.88
纯度 98.65%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 ABC 99|ABC-99

体外活性

ABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner and preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner[1].

溶解度

DMSO:20 mg/mL (43.8 mM),ultrasonic and heat to 80°C

参考文献

1.Suciu RM, et al. Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling. ACS Med Chem Lett. 2018;9(6):563-568.

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