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ABL1 Polyclonal antibody, PBS Only

ABL1 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 29725-1-PBS

Print datasheet

Synonyms

c ABL, p150, JTK7, EC:2.7.10.2, ABL

验证数据展示

  • WB analysis using 29725-1-AP (same clone as 29725-1-PBS)

    WB analysis using 29725-1-AP (same clone as 29725-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 29725-1-AP (ABL1 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29725-1-PBS in a different storage buffer formulation.

产品信息

29725-1-PBS targets ABL1 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen Peptide 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name c-abl oncogene 1, receptor tyrosine kinase
Synonyms c ABL, p150, JTK7, EC:2.7.10.2, ABL
Calculated Molecular Weight 1149 aa, 125 kDa
Observed Molecular Weight140 kDa
GenBank Accession NumberBC117451
Gene Symbol ABL1
Gene ID (NCBI) 25
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP00519
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ABL1, also named as ABL, JTK7, c-ABL and p150, belongs to the protein kinase superfamily, Tyr protein kinase family and ABL subfamily. ABL1 regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. ABL1 localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. It regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. ABL1 catalyze the reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia (CML) [MIM:608232]. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).