ACSS1 Monoclonal antibody, PBS Only

ACSS1 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 68608-1-PBS

产品说明书

CloneNo. 3E10F11

宿主/亚型

Mouse / IgG2b

种属反应性

Human, Mouse, Rat

应用

WB, Indirect ELISA

ACAS2L, AceCS2, AceCS2L, Acetate CoA ligase 2, Acetyl CoA synthetase 2, ACSS1, FLJ45659, KIAA1846

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


产品信息

68608-1-PBS targets ACSS1 in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 Human, Mouse, Rat
免疫原 ACSS1 fusion protein Ag10853 种属同源性预测
宿主/亚型 Mouse / IgG2b
抗体类别 Monoclonal
产品类型 Antibody
全称 acyl-CoA synthetase short-chain family member 1
别名 ACAS2L, AceCS2, AceCS2L, Acetate CoA ligase 2, Acetyl CoA synthetase 2, ACSS1, FLJ45659, KIAA1846
计算分子量 689 aa, 75 kDa
观测分子量 70-75 kDa
GenBank蛋白编号BC039261
基因名称 ACSS1
Gene ID (NCBI) 84532
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ9NUB1
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The ACSS (acetyl-CoA synthetase) enzyme is the sole known mammalian enzyme that can catalyze the conversion of free acetate into acetyl coenzyme A (acetyl-CoA). The three known isoforms of human ACSS are termed ACSS1, ACSS2, and ACSS3. The main substrate of ACSS1 and ACSS2 is acetate, while the preferential substrate of ACSS3 is propionate. Two acetate related enzymes, ACSS1(GeneID: 84532) and ACSS2 (GeneID:55902) difer in their tissue distribution and subcellular localization. On the one hand, as a mitochondrial matrix enzyme, ACSS1 is expressed mainly in cardiac and skeletal muscle as well as brown adipose tissue. On the other hand, as a nuclear and cytoplasmic enzyme, ACSS2 is strongly expressed in the liver, kidney and heart and moderately expressed in the brain and testis.ACSS2 participates in lipid synthesis and facilitates protein acetylation by generating acetyl-CoA, while ACSS1 is involved in acetate oxidation. The functional diferences in these enzymes involve energy production through the tricarboxylic acid (TCA) cycle. Due to its more thorough utilization of intracellular acetate, ACSS2 is expressed in almost all cell types under diferent physiological conditions.

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