验证数据展示
经过测试的应用
| Positive WB detected in | HEK-293 cells, DMSO treated HepG2 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:200-1:1000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
10086-1-AP targets ACVR1B in WB, IHC, IF, ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, ELISA Application Description |
| 文献引用应用 | WB, IHC, IF |
| 经测试反应性 | human |
| 文献引用反应性 | human, mouse, rat |
| 免疫原 | ACVR1B fusion protein Ag0129 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | activin A receptor, type IB |
| 别名 | activin A receptor, type IB, Activin receptor like kinase 4, Activin receptor type 1B, Activin receptor type IB, ACTR IB, ACTRIB, ACVR1B, ACVRLK4, ALK 4, ALK4, SKR2 |
| 计算分子量 | 57 kDa |
| 观测分子量 | 50 kDa |
| GenBank蛋白编号 | BC000254 |
| 基因名称 | ACVR1B |
| Gene ID (NCBI) | 91 |
| RRID | AB_2877723 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P36896 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
ACVR1B (ALK4, activin A receptor type 1B) is a transforming growth factor-beta (TGF-beta) superfamily member (PMID: 37020544). A potential role for ACVR1B in regulating muscle mass is that it is part of the transforming growth factor b (TGFb) pathway regulating myostatin (PMID: 21063444).
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for ACVR1B antibody 10086-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
J Am Heart Assoc Activin Receptor-Like Kinase 4 Haplodeficiency Mitigates Arrhythmogenic Atrial Remodeling and Vulnerability to Atrial Fibrillation in Cardiac Pathological Hypertrophy. | ||
Mol Cell Endocrinol ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells. | ||
Animals (Basel) Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B. | ||
J Toxicol Sci Salvianolic acid B attenuated cisplatin-induced cardiac injury and oxidative stress via modulating Nrf2 signal pathway. | ||
Bioact Mater Bioprinted constructs that simulate nerve-bone crosstalk to improve microenvironment for bone repair |
