ACVRL1 Polyclonal antibody

ACVRL1 Polyclonal Antibody for WB, IP, IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (1)

Applications

WB, IP, IHC, ELISA

Conjugate

Unconjugated

Cat no : 14745-1-AP

Print datasheet

Synonyms

Activin receptor like kinase 1, ACVRL1, ACVRLK1, ALK 1, ALK1, HHT, HHT2, ORW2, SKR3, TSR I



经过测试的应用

Positive WB detected inhuman placenta tissue
Positive IP detected inJurkat cells
Positive IHC detected inhuman heart tissue, human lymphoma tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

14745-1-AP targets ACVRL1 in WB, IP, IHC, ELISA applications and shows reactivity with human samples.

Tested Applications WB, IP, IHC, ELISA Application Description
Cited ApplicationsWB, IP, IHC
Tested Reactivity human
Cited Reactivityhuman, mouse
Immunogen ACVRL1 fusion protein Ag6449 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name activin A receptor type II-like 1
Synonyms Activin receptor like kinase 1, ACVRL1, ACVRLK1, ALK 1, ALK1, HHT, HHT2, ORW2, SKR3, TSR I
Calculated Molecular Weight 56 kDa
Observed Molecular Weight 63 kDa
GenBank Accession NumberBC042637
Gene Symbol ACVRL1
Gene ID (NCBI) 94
RRIDAB_2222474
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP37023
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

ACVRL1 (also known as ALK1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. ACVRL1 is highly expressed in endothelial cells and has a critical role in the control of blood vessel development and repair (PMID: 8640225). Mutations in the ACVRL1 gene are associated with hemorrhagic telangiectasia type 2.

实验方案

Product Specific Protocols
WB protocol for ACVRL1 antibody 14745-1-APDownload protocol
IHC protocol for ACVRL1 antibody 14745-1-APDownload protocol
IP protocol for ACVRL1 antibody 14745-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
mouse,humanWB

Mol Cell

OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin.

Authors - Yesheng Fu
humanWB,FC

Nat Commun

Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils.

Authors - Yusuke Kimishima
humanWB

J Mol Cell Cardiol

BMP9 attenuates occurrence of venous malformation by maintaining endothelial quiescence and strengthening vessel walls via SMAD1/5/ID1/α-SMA pathway.

Authors - Yongyun Li
humanWB,IP

Cell Biol Int

CHRDL2 promotes osteosarcoma cell proliferation and metastasis through the BMP-9/ PI3K/ AKT pathway.

Authors - Houping Chen
humanIHC

J Thorac Dis

Pulmonary inflammatory myofibroblastic tumor versus IgG4-related inflammatory pseudotumor: differential diagnosis based on a case series.

Authors - Longfei Zhu
mouseWB,IHC

Biosci Biotechnol Biochem

BMP9 functions as a negative regulator in the myogenic differentiation of primary mouse myoblasts

Authors - Xiya Lu