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AChE/BChE/MAO-B-IN-1

AChE/BChE/MAO-B-IN-1是一种可逆的、非时间依赖且可透过血脑屏障的AChE、BChE 和MAO-B 抑制剂，对 hAChE、hBChE 和 hMAO-B 表现出抑制作用，IC50分别为 7.31、0.56 和 26.1 μM。AChE/BChE/MAO-B-IN-1具有神经保护作用且无明显细胞毒性。

CAS号

2416910-82-0

分子式

C20H24N2O2

主要靶点

MAO|AChE

仅限科研使用

Cat No : CM07092

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Synonyms

验证数据展示

  • CAS No.: 2416910-82-0

    AChE/BChE/MAO-B-IN-1
    CAS#: 2416910-82-0

产品信息

AChE/BChE/MAO-B-IN-1 is a reversible, non-time-dependent inhibitor of AChE, BChE and MAO-B that crosses the blood-brain barrier and exhibits inhibitory effects on hAChE, hBChE and hMAO-B with IC50s of 7.31, 0.56 and 26.1 μM, respectively. 1 had a neuroprotective effect and was not significantly cytotoxic.

CAS号 2416910-82-0
分子式 C20H24N2O2
主要靶点 MAO|AChE
主要通路 神经科学|代谢
分子量 324.42
纯度 99.69%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
别名

靶点活性

MAO-B:26.1 μM|BChE:0.56 μM|AChE:7.31 μM

体外活性

AChE/BChE/MAO-B-IN-1 inhibits neuronal cell death induced by amyloid β 1-42 (Aβ 1-42).[1]

溶解度

DMSO:27.5 mg/mL (84.77 mM)

参考文献

1.Košak U, et al. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents. Eur J Med Chem. 2020 ; 197:112282.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2