Angiotensinogen Monoclonal antibody
Angiotensinogen Monoclonal Antibody for ELISA
Host / Isotype
Mouse / IgG2b
Reactivity
human
Applications
ELISA
Conjugate
Unconjugated
CloneNo.
2H2A10
验证数据展示
Planning an IHC experiment? We recommend our IHCeasy AGT Ready-To-Use IHC Kit. AGT primary antibody included.
产品信息
60126-1-Ig targets Angiotensinogen in ELISA applications and shows reactivity with human samples.
Tested Applications | ELISA Application Description |
Tested Reactivity | human |
Cited Reactivity | human |
Immunogen | Angiotensinogen fusion protein Ag2632 种属同源性预测 |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Full Name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
Synonyms | AGT, Ang I Angiotensin 2, Ang II Angiotensin 3, Ang III, Angiotensin, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensinogen, ANHU, Des Asp[1] angiotensin II, Serpin A8, SERPINA8 |
Calculated Molecular Weight | 485 aa, 53 kDa |
Observed Molecular Weight | 52 kDa |
GenBank Accession Number | BC011519 |
Gene Symbol | AGT |
Gene ID (NCBI) | 183 |
RRID | AB_2225451 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P01019 |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Angiotensinogen is a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
发表文章
Species | Application | Title |
---|---|---|
Cells Effect of Hydrocortisone on Angiotensinogen (AGT) Mutation-Causing Autosomal Recessive Renal Tubular Dysgenesis. |