CoraLite®594-conjugated Angiotensinogen/AGT Monoclonal antibody
Angiotensinogen/AGT Monoclonal Antibody for
Host / Isotype
Mouse / IgG2b
Reactivity
human, pig
Applications
Conjugate
CoraLite®594 Fluorescent Dye
CloneNo.
1B2F5
验证数据展示
Planning an IHC experiment? We recommend our IHCeasy AGT Ready-To-Use IHC Kit. AGT primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 68020-1-Ig
产品信息
CL594-68020 targets Angiotensinogen/AGT in applications and shows reactivity with human, pig samples.
| Tested Applications | Application Description |
| Tested Reactivity | human, pig |
| Immunogen | Angiotensinogen/AGT fusion protein Ag16658 种属同源性预测 |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
| Synonyms | AGT, Angiotensinogen, Serpin A8, SERPINA8, 1B2F5 |
| Calculated Molecular Weight | 485 aa, 53 kDa |
| Observed Molecular Weight | 52 kDa |
| GenBank Accession Number | BC011519 |
| Gene Symbol | AGT |
| Gene ID (NCBI) | 183 |
| RRID | AB_2934793 |
| Conjugate | CoraLite®594 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 588 nm / 604 nm |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P01019 |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Angiotensinogen is a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene also have been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
