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AK-1

AK-1是一种特异性有效和细胞可渗透的SIRT2抑制剂，其IC50值为 12.5 μM。它可防止阿尔茨海默病模型中的海马神经退行性变并诱导结肠癌细胞中的细胞周期停滞。

CAS号

330461-64-8

分子式

C19H21N3O5S

主要靶点

Sirtuin

仅限科研使用

Cat No : CM11548

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Synonyms

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  • CAS No.: 330461-64-8

    AK-1
    CAS#: 330461-64-8

产品信息

AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 μM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.

CAS号 330461-64-8
分子式 C19H21N3O5S
主要靶点 Sirtuin
主要通路 表观遗传|DNA损伤和修复
分子量 403.45
纯度 99.01%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

SIRT2:12.5 μM

体外活性

AK-1 induces the formation of α-synuclein aggregates in H4 neuroglioma cells expressing α-synuclein and synphilin-1.AK-1 (5 μM) decreases total cholesterol levels in Neuro2a and primary rat striatal neurons, as well as in hippocampal slice cultures[1].

溶解度

DMSO:50 mg/mL (123.93 mM)

参考文献

1.Taylor D M , Balabadra U , Xiang Z , et al. A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase[J]. ACS Chemical Biology, 2011, 6(6):540-546.
2.Outeiro T F , Kontopoulos E , Altmann S M , et al. Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease[J]. Science, 317.

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