AK-7

MW = 437.4
C₁₉H₂₁BrN₂O₃S
CAS 420831-40-9
MP = 148-151°C
>98% (TLC); NMR (Conforms)

A selective Sirt2 inhibitor (IC₅₀ = 15.5 M) which does not bind Sirt1 or Sirt3 (ref 1). It down-regulates cholesterol biosynthesis genes in primary striatal neurons (ref 1). Displays neuroprotective effects in Huntington's disease mouse models including improved motor function, extended survival and reduce brain atrophy all of which were associated with reduced aggregated mutant huntingtin (ref 2).

White powder. May be dissolved in DMSO (50 mg/ml); Ethanol (8 mg/ml, warm).

Store desiccated as supplied at room temperature for up to 3 years. Store solutions at -20°C for up to 3 months.

1. DM Taylor et al. ACS Chem. Biol. 2011, 6:540
2. V Chopra et al. Cell Rep. 2012, 2:1492