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AKR1C1-IN-1

AKR1C1-IN-1 是高选择性 AKR1C1抑制剂(Ki:4 nM)。

CAS号

4906-68-7

分子式

C13H9BrO3

主要靶点

NADPH

仅限科研使用

Cat No : CM02599

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Synonyms

验证数据展示

  • CAS No.: 4906-68-7

    AKR1C1-IN-1
    CAS#: 4906-68-7

产品信息

AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase (AKR1C1) inhibitor (Ki: 4 nM for AKR1C1).

CAS号 4906-68-7
分子式 C13H9BrO3
主要靶点 NADPH
主要通路 代谢
分子量 293.12
纯度 99.44%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

AKR1C2:87 nM (Ki)|AKR1C3:4.2 μM (Ki)|AKR1C1:4 nM (Ki)|AKR1C4:18.2 μM (Ki)

体外活性

AKR1C1-IN-1 inhibits the metabolism of progesterone that in AKR1C1-overexpressed BAECs (IC50:460 nM).

溶解度

DMSO:27.5 mg/mL (93.82 mM)

参考文献

1.El-Kabbani O, et al. Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1). J Med Chem. 2009 May 28;52(10):3259-64.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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=
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C1   V1   C2   V2