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ALK2-IN-2

ALK2-IN-2是一种强效且具有选择性激活素受体样激酶2（ALK2）的抑制剂（IC50：9 nM），对 ALK2的抑制作用比 ALK3高700倍。

CAS号

2254409-25-9

分子式

C28H27N5O2S

主要靶点

TGF-beta/Smad|ALK

仅限科研使用

Cat No : CM09500

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Synonyms

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  • CAS No.: 2254409-25-9

    ALK2-IN-2
    CAS#: 2254409-25-9

产品信息

ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.

CAS号 2254409-25-9
分子式 C28H27N5O2S
主要靶点 TGF-beta/Smad|ALK
主要通路 干细胞|蛋白酪氨酸激酶|血管生成
分子量 497.61
纯度 99.55%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

ALK2:9 nM

溶解度

DMSO:112.5 mg/mL (226.1 mM),Sonification is recommended.

参考文献

1.Jiang JK, et al. Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorg Med Chem Lett. 2018 ; 28(20):3356-3362.

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