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ALMS1 Polyclonal antibody

ALMS1 Polyclonal Antibody for IF/ICC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, ELISA

Conjugate

Unconjugated

Cat no : 27231-1-AP

Print datasheet

Synonyms

ALMS1, ALSS, Alstrom syndrome 1, Alstrom syndrome protein 1, KIAA0328

验证数据展示

  • IF Staining of HeLa using 27231-1-AP

    IF Staining of HeLa using 27231-1-AP

    Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using 27231-1-AP (ALMS1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L).

经过测试的应用

Positive IF/ICC detected inHeLa cells

推荐稀释比

ApplicationDilution
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

27231-1-AP targets ALMS1 in IF/ICC, ELISA applications and shows reactivity with human samples.

Tested Applications IF/ICC, ELISA Application Description
Tested Reactivity human
Immunogen ALMS1 fusion protein Ag26100 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name Alstrom syndrome 1
Synonyms ALMS1, ALSS, Alstrom syndrome 1, Alstrom syndrome protein 1, KIAA0328
Calculated Molecular Weight 461 kDa
GenBank Accession NumberNM_015120
Gene Symbol ALMS1
Gene ID (NCBI) 7840
RRIDAB_2880812
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ8TCU4
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

ALMS1 (Alstrom syndrome protein 1) is also KIAA0328. ALMS1 encodes a ~ 0.5 megadalton protein that localises to the base of centrioles. Some studies have suggested a role for this protein in maintaining centriole-nucleated sensory organelles termed primary cilia, and AS is now considered to belong to the growing class of human genetic disorders linked to ciliary dysfunction (ciliopathies). The ALMS1 protein is a component of the centrosome (PMID:30421101). ALMS1 is involved in PCM1-dependent intracellular transport. ALMS1 is required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. It is required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells.

实验方案

Product Specific Protocols
IF protocol for ALMS1 antibody 27231-1-APDownload protocol
FC protocol for ALMS1 antibody 27231-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols