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BML-284 hydrochloride

BML-284 hydrochloride (Wnt agonist 1 HCL) 是细胞通透性 Wnt 信号激活剂。它能够诱导 TCF 依赖的转录活性(EC50>700 nM)。

CAS号

2095432-75-8

分子式

C19H19ClN4O3

主要靶点

Wnt/beta-catenin

仅限科研使用

Cat No : CM06900

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Synonyms

BML-284 HCL|Wnt agonist 1 HCL

验证数据展示

  • CAS No.: 2095432-75-8

    BML-284 hydrochloride
    CAS#: 2095432-75-8

产品信息

BML-284 hydrochloride (Wnt agonist 1 HCL) is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.

CAS号 2095432-75-8
分子式 C19H19ClN4O3
主要靶点 Wnt/beta-catenin
主要通路 细胞骨架|干细胞
分子量 386.84
纯度 99.79%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 BML-284 HCL|Wnt agonist 1 HCL

靶点活性

wnt signaling:700 nM (EC50)

体内活性

In a Xenopus model, Wnt agonist 1 (10 μM) mimics the effects of Wnt at the whole-organism level, and affects Xenopus embryonic head specification.

体外活性

BML-284 HCL does not inhibit the activity of GSK-3β, and may be a useful tool in the study of physiological processes that involve the Wnt pathway.

溶解度

DMSO:9 mg/mL (23.27 mM)

参考文献

1.Angew Chem Int Ed Engl. 2005, 44(13), 1987-1990.

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