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AP-1/NF-κB activation inhibitor 1

AP-1/NF-κB activation inhibitor 1 是一种有效的 AP-1和 NF-κB 介导的转录激活抑制剂(IC50=1 μM)，不阻断 β-actin 启动子驱动的基础转录。AP-1/NF-κB activation inhibitor 1 对受刺激细胞中 IL-2和 IL-8的产生水平有相似的抑制作用。

CAS号

188936-12-1

分子式

C13H11F3N4O4

主要靶点

DNA/RNA Synthesis|NF-κB

仅限科研使用

Cat No : CM11981

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Synonyms

验证数据展示

  • CAS No.: 188936-12-1

    AP-1/NF-κB activation inhibitor 1
    CAS#: 188936-12-1

产品信息

AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells [1].

CAS号 188936-12-1
分子式 C13H11F3N4O4
主要靶点 DNA/RNA Synthesis|NF-κB
主要通路 NF-κB信号通路|DNA损伤和修复|细胞周期
分子量 344.25
纯度 99.74%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

溶解度

DMSO:225mg/mL (653.6mM),Sonification is recommended.

参考文献

1.Palanki MS, et al. Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate. Bioorg Med Chem Lett. 2000;1

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