APP Polyclonal antibody
APP Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human and More (2)
Applications
ELISA and More (1)
Conjugate
Unconjugated
验证数据展示
发表文章中的应用
| WB | See 3 publications below |
产品信息
10524-1-AP targets APP in WB, ELISA applications and shows reactivity with human samples.
| Tested Applications | ELISA Application Description |
| Cited Applications | WB |
| Tested Reactivity | human |
| Cited Reactivity | human, mouse, rat |
| Immunogen | APP fusion protein Ag0769 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | amyloid beta (A4) precursor protein |
| Synonyms | amyloid precursor protein, Alzheimer disease amyloid protein, Alzheimer disease amyloid A4 protein homolog, AD1, AB42 |
| Calculated Molecular Weight | 87 kDa |
| GenBank Accession Number | BC004369 |
| Gene Symbol | APP |
| Gene ID (NCBI) | 351 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P05067 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1). This antibody can recogniaze the N-terminus of human APP: Soluble APP-alpha and Soluble APP-beta.
发表文章
| Species | Application | Title |
|---|---|---|
Neurobiol Aging Beta amyloid-induced upregulation of death receptor 6 accelerates the toxic effect of N-terminal fragment of amyloid precursor protein. | ||
Int J Biol Macromol Polysaccharides from Pleurotus ostreatus alleviate cognitive impairment in a rat model of Alzheimer's disease. | ||
Neurotoxicology Protective mechanism of gold nanoparticles on human neural stem cells injured by β-amyloid protein through miR-21-5p/SOCS6 pathway |