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APY29

APY29 是 IRE1α 的变构调节剂；抑制 IRE1α 自磷酸化，IC50值为 280 nM，并激活 IRE1α RNase 活性。

CAS号

1216665-49-4

分子式

C17H16N8

主要靶点

IRE1

仅限科研使用

Cat No : CM04860

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Synonyms

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  • CAS No.: 1216665-49-4

    APY29
    CAS#: 1216665-49-4

产品信息

APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.

CAS号 1216665-49-4
分子式 C17H16N8
主要靶点 IRE1
主要通路 细胞周期
分子量 332.36
纯度 96.51%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

IRE1α:280 nM

体外活性

APY29 divergently modulates the RNase activity and oligomerization state of IRE1α by exerting their opposing effects on RNase activity through the same binding site. APY29 divergently affects IRE1α oligomerization. APY29 demonstrates opposing dose-dependent effects on ER stress-induced activation of the RNase of endogenous IRE1α[1].

溶解度

DMSO:33.24 mg/mL (100 mM)

参考文献

1.Wang, L., Perera, B., Hari, S., Bhhatarai, B., Backes, B., & Seeliger, M. et al. (2012). Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nature Chemical Biology, 8(12), 982-989. doi: 10.1038/nchembio.1094

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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