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ARN25068

ARN25068是三种蛋白激酶(GSK-3β、FYN和DYRK1A)的亚微摩尔抑制剂，可用于治疗tau相关神经系统疾病。

CAS号

2649882-80-2

分子式

C19H18N6S

主要靶点

DYRK|Src|Microtubule Associated|GSK-3

仅限科研使用

Cat No : CM17817

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Synonyms

验证数据展示

  • CAS No.: 2649882-80-2

    ARN25068
    CAS#: 2649882-80-2

产品信息

ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation [1].

CAS号 2649882-80-2
分子式 C19H18N6S
主要靶点 DYRK|Src|Microtubule Associated|GSK-3
主要通路 细胞周期|干细胞|细胞骨架|PI3K/Akt/mTOR信号通路|蛋白酪氨酸激酶|血管生成
分子量 362.45
纯度 99.71%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
别名

靶点活性

GSK-3β:4.17 μM|FYN:2.17 μM

体外活性

ARN25068 diminishes tau phosphorylation levels in the Tau0N4R-TM-tGFP U2OS cell line.[1]

参考文献

1.Demuro S, et al. ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem. 2022;229:114054.
2.Lindberg MF, et al. Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases. J Med Chem. 2023;66(6):4106-4130.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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