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ARP-100

ARP-100 (MMP-2 Inhibitor III) 是选择性基质金属蛋白酶MMP-2抑制剂 (IC50=12 nM)。它对 MMP-1 (>50 μM)，MMP-3 (4.5 μM)，MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。它与 MMP-2 的 S1＇口袋相互作用，并在体外对基质胶的侵袭模型中显示抗侵袭特性。

CAS号

704888-90-4

分子式

C17H20N2O5S

主要靶点

MMP

仅限科研使用

Cat No : CM05190

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Synonyms

MMP-2 Inhibitor III

验证数据展示

  • CAS No.: 704888-90-4

    ARP-100
    CAS#: 704888-90-4

产品信息

ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with the S1' pocket of MMP-2 and exhibits anti-invasive properties in an in vitro invasion Matrigel model. ARP-100 has low inhibitory activity against MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM) and MMP-9 (0.2 μM)[1][2].

CAS号 704888-90-4
分子式 C17H20N2O5S
主要靶点 MMP
主要通路 蛋白酶体
分子量 364.42
纯度 98.34%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 MMP-2 Inhibitor III

靶点活性

MMP-3:4.5 μM|MMP-7:>50 μM|MMP-2:12 nM|MMP-1:>50 μM|MMP-9:0.2 μM

体外活性

ARP-100 (50 nM) exhibits a significant reduction in the total number of invasive elongations[1].

溶解度

DMSO:96 mg/mL (263.43 mM),Sonification is recommended.

参考文献

1.Rossello A, et al. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2). Bioorg Med Chem. 2004 May 1;12(9):2441-50.
2.Tuccinardi T, et al. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides. Bioorg Med Chem. 2006 Jun 15;14(12):4260-76.

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