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Abametapir

Abametapir (BRN 0123183) 是一种金属蛋白酶抑制剂，能够靶向对卵孵化和虱子发育至关重要的金属蛋白酶。

CAS号

1762-34-1

分子式

C12H12N2

主要靶点

MMP|Others|Parasite

仅限科研使用

Cat No : CM01797

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Synonyms

BRN 0123183|5 5'-二甲基-2,2-联吡啶|HA-44

验证数据展示

  • CAS No.: 1762-34-1

    Abametapir
    CAS#: 1762-34-1

产品信息

Abametapir, a metalloproteinase inhibitor, is able to target metalloproteinases critical to egg hatching and louse development.

CAS号 1762-34-1
分子式 C12H12N2
主要靶点 MMP|Others|Parasite
主要通路 蛋白酶体|其他|微生物学
分子量 184.24
纯度 98.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 BRN 0123183|5 5'-二甲基-2,2-联吡啶|HA-44

体外活性

Bbametapir was 100% ovicidal against eggs of all ages when evaluated at a concentration of 0.37 and 0.55%.

溶解度

DMSO:37mg/mL(200.83mM)

参考文献

1.Bowles VM, Hanegraaf S, Ahveninen T.et al.Effect of a New Head Lice Treatment, Abametapir Lotion, 0.74%, on Louse Eggs: A Randomized, Double-Blind Study.Glob Pediatr Health. 2019 Feb 22.
2.Bowles, Vernon, M, et al. Clinical studies evaluating abametapir lotion, 0.74%, for the treatment of head louse infestation[J]. Pediatric dermatology, 2018.

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