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Acotiamide monohydrochloride trihydrate

Acotiamide monohydrochloride trihydrate (Z-338 HCl) 是一种首创的、具有口服活性的胃肠动力药。它通过促毒蕈碱受体拮抗作用和乙酰胆碱酯酶(AChE)抑制作用增强肠神经元释放的乙酰胆碱，从而增强胃排空和胃部适应性，有潜力用于功能性消化不良的研究。

CAS号

773092-05-0

分子式

C21H37ClN4O8S

主要靶点

AChE

仅限科研使用

Cat No : CM01443

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Synonyms

Acotiamide hydrochloride|YM-443 HCl|Z-338 HCl|盐酸阿考替胺

验证数据展示

  • CAS No.: 773092-05-0

    Acotiamide monohydrochloride trihydrate
    CAS#: 773092-05-0

产品信息

Acotiamide monohydrochloride trihydrate (Z-338 HCl) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.

CAS号 773092-05-0
分子式 C21H37ClN4O8S
主要靶点 AChE
主要通路 神经科学
分子量 541.06
纯度 99.48%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Acotiamide hydrochloride|YM-443 HCl|Z-338 HCl|盐酸阿考替胺

溶解度

DMSO:27.5 mg/mL (50.83 mM)

参考文献

1.Kawachi M,et al. Eur J Pharmacol. 2011 Sep;666(1-3):218-25.

The molarity calculator equation

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The dilution calculator equation

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