Acrivastine

Acrivastine (Acrivastin) 是一种短效组胺 1 受体拮抗剂,可用于研究过敏性鼻炎。

CAS号

87848-99-5

分子式

C22H24N2O2

主要靶点

Histamine Receptor

仅限科研使用

Cat No : CM04478

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Synonyms

Semprex|BW825C|阿伐斯汀|Acrivastin



产品信息

Acrivastine is a short-acting histamine 1 receptor antagonist.

CAS号 87848-99-5
分子式 C22H24N2O2
主要靶点 Histamine Receptor
主要通路 神经科学|免疫与炎症|G蛋白偶联受体
分子量 348.44
纯度 99.85%, 此纯度可做参考,具体纯度与批次有关系,可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Semprex|BW825C|阿伐斯汀|Acrivastin

体内活性

Acrivastine (usually 8mg three times daily) is an effective and well-tolerated antihistamine in the treatment of chronic urticaria and allergic rhinitis. Acrivastine causes less drowsiness than clemastine, the incidence of adverse effects being indistinguishable from that with placebo or terfenadine. In the treatment of dermatoses in which histamine has a pathogenetic role, the efficacy of acrivastine is superior to that of placebo and similar to that of usual dosages of clemastine, hydroxyzine, chlorpheniramine, cyproheptadine or terfenadine [1]. Both 4 mg and 8 mg acrivastine alleviate the symptoms of seasonal allergic rhinitis with significant improvements in the symptom scores for sneezing, running nose and the calculated overall score. In addition, 8 mg acrivastine reduces the symptom scores for watery eyes and itchy throat. Acrivastine is both well tolerated and effective in the treatment of seasonal allergic rhinitis [2].

溶解度

DMSO:10 mg/mL,warmed&ultrasonic

参考文献

1.Brogden RN, et al. Acrivastine. A review of its pharmacological properties and therapeutic efficacy in allergic rhinitis, urticaria and related disorders. Drugs. 1991 Jun;41(6):927-40.
2.Gibbs TG, et al. Acrivastine in two doses compared with placebo in a multicentre, parallel group study for the treatment of seasonal allergic rhinitis. Br J Clin Pract. 1989 Jan;43(1):11-4.

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