• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Adavivint

Adavivint (Adavivint (SM04690)) (SM04690) 是选择性的典型的Wnt 信号通路抑制剂，在 SW480 细胞中，用高通量 TCF/LEF 报告基因实验，测得EC50=19.5 nM。

CAS号

1467093-03-3

分子式

C29H24FN7O

主要靶点

Wnt/beta-catenin

仅限科研使用

Cat No : CM06898

Print datasheet

Synonyms

Adavivint (SM04690)

验证数据展示

  • CAS No.: 1467093-03-3

    Adavivint
    CAS#: 1467093-03-3

产品信息

Adavivint (SM04690) is a Wnt pathway inhibitor.

CAS号 1467093-03-3
分子式 C29H24FN7O
主要靶点 Wnt/beta-catenin
主要通路 细胞骨架|干细胞
分子量 505.55
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Adavivint (SM04690)

靶点活性

Wnt, SW480 cell:19.5 nM (EC50)

体内活性

Adavivint (SM04690) is a?novel Wnt pathway inhibitor, for the treatment of moderate to severe osteoarthritis of the knee.

溶解度

DMSO:Slightly soluble

动物实验

A high-throughput screen was performed using a cell-based reporter assay for Wnt pathway activity to develop a small molecule designated SM04690. Its properties were evaluated in bone-marrow-derived human mesenchymal stem cells (hMSCs) to assess chondrocyte differentiation and effects on cartilage catabolism by immunocytochemistry and gene expression, and glycosaminoglycan breakdown. In vivo effects of SM04690 on Wnt signaling, cartilage regeneration and protection were measured using biochemical and histopathological techniques in a rodent acute cruciate ligament tear and partial medial meniscectomy (ACLT + pMMx) OA model.

参考文献

1.Yazici Y , Mcalindon T E , Fleischmann R , et al. A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study[J]. Osteoarthritis & Cartilage, 2017, 25(10):1598.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2