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Aloisine B

Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively. Aloisine B has antiviral activity and can be used to study Alzheimer's, diabetes, HIV and Parkinson's.

CAS号

496864-14-3

分子式

C15H14ClN3

主要靶点

CDK|GSK-3

仅限科研使用

Cat No : CM14368

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Synonyms

AloisineB

验证数据展示

  • CAS No.: 496864-14-3

    Aloisine B
    CAS#: 496864-14-3

产品信息

Aloisine B is a potent and selective CDK and GSK-3 inhibitor. Highest affinity targets: Glycogen Synthase Kinase-3, Beta (Rattus norvegicus (rat)) (IC50 750.0 nM). Other measured targets: Cyclin-Dependent Kinase 1 (CDK1) (IC50 850.0 nM); Cyclin-Dependent Kinase 5 (CDK5) (IC50 13000.0 nM). Aloisine inhibits cell proliferation by arresting cells in both G1 and G2.

CAS号 496864-14-3
分子式 C15H14ClN3
主要靶点 CDK|GSK-3
主要通路 细胞周期|PI3K/Akt/mTOR信号通路|干细胞
分子量 271.74
纯度 95.15%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
别名 AloisineB

参考文献

1.Mettey Y, et al. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36.

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