验证数据展示
产品信息
66221-1-PBS targets Alpha E-Catenin in Indirect ELISA, IHC, WB applications and shows reactivity with mouse, human samples.
经测试应用 | Indirect ELISA, IHC, WB Application Description |
经测试反应性 | mouse, human |
免疫原 | Alpha E-Catenin fusion protein Ag23603 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | catenin (cadherin-associated protein), alpha 1, 102kDa |
别名 | CTNNA1, Catenin alpha 1, CAP102, Alpha E catenin, alpha catenin |
计算分子量 | 906 aa, 100 kDa |
观测分子量 | 95-100 kDa |
GenBank蛋白编号 | BC031262 |
基因名称 | Alpha E-Catenin |
Gene ID (NCBI) | 1495 |
RRID | AB_2881612 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | P35221 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Alpha catenin is an essential component of adherens junctions that connects E-cadherin-β-catenin complexes with the actin cytoskeleton. It also recruits a range of other important proteins to developing intercellular junctions. Three alpha catenins exist in human: alpha-E-catenin, alpha-N-catenin, and alpha-T-catenin, which share substantial amino-acid sequence similarity but have distinct tissue distribution. alpha-E-catenin is ubiquitously expressed, alpha-N-catenin is restricted to neuronal tissue, and alpha-T-catenin is primarily expressed in heart tissue. Reduced levels of alpha-E-catenin protein seem to be characteristic of many different human cancers, including malignant tumours of the breast, colon, stomach, oesophagus, bladder and liver. In addition, the loss of alpha-E-catenin often correlates with the degree of tumour differentiation and metastasis.