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Amentoflavone

Amentoflavone (3',8''-Biapigenin) 是一种具有很多生物活性的双黄酮类天然产物，有抗炎、抗氧化和神经保护等作用。

CAS号

1617-53-4

分子式

C30H18O10

主要靶点

Reactive Oxygen Species|Apoptosis|Antibacterial|P450|Antifungal|RSV|Opioid Receptor|COX|Phospholipase

仅限科研使用

Cat No : CM06725

Print datasheet

Synonyms

Amenthoflavone|Didemethyl-ginkgetin|穗花杉双黄酮|3',8''-Biapigenin

验证数据展示

  • CAS No.: 1617-53-4

    Amentoflavone
    CAS#: 1617-53-4

产品信息

Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.

CAS号 1617-53-4
分子式 C30H18O10
主要靶点 Reactive Oxygen Species|Apoptosis|Antibacterial|P450|Antifungal|RSV|Opioid Receptor|COX|Phospholipase
主要通路 代谢|G蛋白偶联受体|微生物学|NF-κB信号通路|凋亡|免疫与炎症|内分泌与激素|神经科学
分子量 538.46
纯度 98.81%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Amenthoflavone|Didemethyl-ginkgetin|穗花杉双黄酮|3',8''-Biapigenin

溶解度

Chloroform, Dichloromethane, Ethyl Acetate:Soluble,DMSO:34 mg/mL（63.14 mM）,Sonification is recommended.

参考文献

1.Sakthivel KM, et al. Int Immunopharmacol. 2013 Nov;17(3):907-16.
2.Lee JS, et al. Phytother Res. 2013 May;27(5):713-20.
3.Yang Y, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jun;34(7):1035-8.
4.Zhang J, et al. Burns. 2014 Aug;40(5):922-9.
5.Kuang Y, Chai Y, Xu L, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin[J]. European Journal of Pharmaceutical Sciences. 2021: 105786.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2