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β-Amyloid (25-35)

CAS号

131602-53-4

分子式

C45H81N13O14S

主要靶点

Beta Amyloid

仅限科研使用

Cat No : CM02694

Print datasheet

Synonyms

inhibit|Amyloid-β|Amyloid beta-peptide|Amyloid β-peptide|Amyloid b-peptide|Amyloid beta-peptide(25-35)|Abeta|Abeta25-35|Ab25-35|b-Amyloid peptide|b-Amyloid|bAmyloid|Aβ25-35|b Amyloid|Beta Amyloid|BetaAmyloid|beta-Amyloid peptide|beta-Amyloid|BETA-淀粉样蛋白片断25-35|β-Amyloid peptide(25-35)|β-Amyloid peptide|β-amyloid peptide|βAmyloid|βAmyloid (2535)|β-Amyloid|β Amyloid|β Amyloid (25 35)|Inhibitor

验证数据展示

  • CAS No.: 131602-53-4

    β-Amyloid (25-35)
    CAS#: 131602-53-4

产品信息

CAS号 131602-53-4
分子式 C45H81N13O14S
主要靶点 Beta Amyloid
主要通路 神经科学
分子量 1060.27
纯度 97.91%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|Amyloid-β|Amyloid beta-peptide|Amyloid β-peptide|Amyloid b-peptide|Amyloid beta-peptide(25-35)|Abeta|Abeta25-35|Ab25-35|b-Amyloid peptide|b-Amyloid|bAmyloid|Aβ25-35|b Amyloid|Beta Amyloid|BetaAmyloid|beta-Amyloid peptide|beta-Amyloid|BETA-淀粉样蛋白片断25-35|β-Amyloid peptide(25-35)|β-Amyloid peptide|β-amyloid peptide|βAmyloid|βAmyloid (2535)|β-Amyloid|β Amyloid|β Amyloid (25 35)|Inhibitor

体内活性

Alzheimer氏病(AD)模型组显示出空间学习和记忆能力受损。CDS和多奈哌齐的给药显著改善了β-Amyloid (25-35)引起的记忆障碍，在Morris水迷宫(P<0.05)和被动避让任务(P<0.01)中与AD模型组相比有显著差异[3]。将β-Amyloid (25-35)通过脑室内注射给大鼠，随后每天给予丹参(CDS)一次，持续23天。采用Morris水迷宫和被动避让任务监测大鼠的行为。通过实时PCR和Western blotting技术检测海马中的淀粉前体蛋白(APP)、β-淀粉样蛋白前体裂解酶-1(BACE1)、前蛋白酶体-1(PS1)、胰岛素降解酶(IDE)和内肽酶(NEP)的表达。

体外活性

β-Amyloid (25-35) 的氨基酸序列为NH2-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-COOH，首个Gly代表第25个氨基酸，末尾的Met代表第35个氨基酸。本研究首次探讨了该多肽在凝胶状态下的特性。研究表明，Amyloid beta-peptide(25-35)能够对分离出的脑线粒体产生凋亡效应，其中methionine-35的氧化还原状态对于程序性细胞死亡途径及其毒性事件的诱导起着关键作用[2]。同时，通过振动吸收光谱和ECD进行了比较研究。此外，利用振动吸收光谱和VCD光谱技术也对Aβ(25-35)多肽膜的构象偏好进行了探究[1]。

溶解度

H2O:3.33 mg/mL (3.14 mM);DMSO:97 mg/mL (91.49 mM)

参考文献

1.D'Ursi AM, et al. Solution structure of amyloid beta-peptide (25-35) in different media. J Med Chem. 2004 Aug 12;47(17):4231-8.
2.Clementi ME, et al. Abeta(31-35) and Abeta(25-35) fragments of amyloid beta-protein induce cellular death throughapoptotic signals: Role of the redox state of methionine-35. FEBS Lett. 2005 May 23;579(13):2913-8.
3.Liu M, et al. Cognitive improvement of compound danshen in an Aβ25-35 peptide-induced rat model of Alzheimer's disease. BMC Complement Altern Med. 2015 Oct 23;15:382.

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