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β-Amyloid (25-35)

β-Amyloid (25-35) (Aβ25-35) 是一种阿尔茨海默氏淀粉样蛋白β肽的Aβ(25-35) 片段，在培养细胞中显示出神经毒性作用。

CAS号

131602-53-4

分子式

C45H81N13O14S

主要靶点

Beta Amyloid

仅限科研使用

Cat No : CM02694

Print datasheet

Synonyms

Aβ25-35|β-Amyloid peptide(25-35)|BETA-淀粉样蛋白片断25-35|Amyloid beta-peptide(25-35)

验证数据展示

  • CAS No.: 131602-53-4

    β-Amyloid (25-35)
    CAS#: 131602-53-4

产品信息

β-Amyloid (25-35) (Aβ25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.

CAS号 131602-53-4
分子式 C45H81N13O14S
主要靶点 Beta Amyloid
主要通路 神经科学
分子量 1060.27
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Aβ25-35|β-Amyloid peptide(25-35)|BETA-淀粉样蛋白片断25-35|Amyloid beta-peptide(25-35)

体内活性

The Alzheimer' s disease (AD) model group present with spatial learning and memory impairments. CDS and donepezil administration significantly ameliorate the Aβ25–35 peptide-induced memory impairment in both Morris water maze (P?

体外活性

The amino acid sequence of Aβ(25-35) peptide is NH2-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-COOH, where the first Gly represents the amino acid 25 and the last Met represents the amino acid 35 and it is also investigated in gel state for the first time. Amyloid beta-peptide(25-35) induces apoptotic effects on isolated brain mitochondria and the redox state of methionine-35, plays a key role in the induction of programmed cellular death pathways and toxic events[2]. Comparative studies are also carried out using vibrational absorption and ECD. The conformational preference of Aβ(25-35) peptide film is also investigated using vibrational absorption and VCD spectroscopy[1].

溶解度

H2O:3.33 mg/mL (3.14 mM),Sonification is recommended.,DMSO:97 mg/mL (91.49 mM),Sonification is recommended.

参考文献

1.D'Ursi AM, et al. Solution structure of amyloid beta-peptide (25-35) in different media. J Med Chem. 2004 Aug 12;47(17):4231-8.
2.Clementi ME, et al. Abeta(31-35) and Abeta(25-35) fragments of amyloid beta-protein induce cellular death throughapoptotic signals: Role of the redox state of methionine-35. FEBS Lett. 2005 May 23;579(13):2913-8.
3.Liu M, et al. Cognitive improvement of compound danshen in an Aβ25-35 peptide-induced rat model of Alzheimer's disease. BMC Complement Altern Med. 2015 Oct 23;15:382.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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