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Anacardic Acid

Anacardic Acid (6-pentadecylsalicylic Acid) 是从腰果壳中提取液中分离到的酸类物质，是一种组蛋白乙酰转移酶抑制剂，对 p300 和 PCAF 的 IC50值分别为 ∼8.5 μM 和 ∼5 μM。

CAS号

16611-84-0

分子式

C22H36O3

主要靶点

Antibacterial|Epigenetic Reader Domain|Others|Histone Acetyltransferase

仅限科研使用

Cat No : CM04512

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Synonyms

Hydroginkgolic acid|6-pentadecylsalicylic Acid|漆树酸

验证数据展示

  • CAS No.: 16611-84-0

    Anacardic Acid
    CAS#: 16611-84-0

产品信息

Anacardic Acid is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostaglandin synthase, lipoxygenase, and tyrosinase.

CAS号 16611-84-0
分子式 C22H36O3
主要靶点 Antibacterial|Epigenetic Reader Domain|Others|Histone Acetyltransferase
主要通路 表观遗传|其他|微生物学
分子量 348.52
纯度 98.84%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Hydroginkgolic acid|6-pentadecylsalicylic Acid|漆树酸

靶点活性

PCAF(p300/CREB-binding protein-associated factor):5 μM|p300(HAT):8.5 μM

体内活性

Anacardic acid decreases over-expression of Gata4, α-MHC, and cTnT in fetal mouse hearts exposed to ethanol. Anacardic acid inhibits binding of PCAF, P300 to the promoter of Gata4.

体外活性

Anacardic acid is an inhibitor of several Clinicalally targeted enzymes such as HATs, NF-kB, LOX-1, xanthine oxidase, tyrosinase, and ureases. Anacardic acid is also an effective inhibitor of Tip60 in vitro. It inhibits the Tip60-dependent acetylation and activation of the ATM protein kinase in HeLa cells and sensitizes the cells to the cytotoxic effects of radiation.

溶解度

Ethanol:17.4 mg/mL (50 mM),DMSO:34.9 mg/mL (100 mM)

细胞实验

HeLa and 293T cells are grown in Dulbecco's modified Eagle's medium/10% fetal calf serum. SQ20B and SCC35 squamous cell carcinoma cell lines are cultured in modified eagles medium/10% fetal calf serum. For anacardic acid (EMD Biosciences, CA) exposure, cells are preincubated with anacardic acid (0-100 μM) for 40 min, irradiated, then allowed to recover for 4 h. Cells are then switched to fresh media and allowed to grow for 10 days.

动物实验

Animal Models: 9 to 11 week old Kunming mice. Formulation: Dissolved in DMSO,co-injected with ethanol. Dosages: 0,1.25,2.5,5,10 mg/kg. Administration: i.p.

参考文献

1.Radde BN, et al.J Cell Biochem. 2016 Mar 17.
2.Yao K, et al.Int J Clin Exp Pathol. 2015 Dec 1;8(12):15926-32. eCollection 2015.
3.Peng C,etal.Inhibition of histone H3K9 acetylation by anacardic acid can correct the over-expression of Gata4 in the hearts of fetal mice exposed to alcohol during pregnancy.PLoS One. 2014 Aug 7;9(8):e104135.
4.Hemshekhar M,etal.Emerging roles of anacardic acid and its derivatives: a pharmacological overview.Basic Clin Pharmacol Toxicol. 2012 Feb;110(2):122-32.
5.Peng C, et al. Phenylephrine-induced cardiac hypertrophy is attenuated by a histone acetylase inhibitor anacardic acid in mice. Mol Biosyst. 2017 Mar 28;13(4):714-724.

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