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Apigenin-7-glucuronide

Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) 能够抑制基质金属蛋白酶的活性，其对 MMP-3 (IC50:12.87 μM)，MMP-8 (IC50:22.39 μM)，MMP-9 (IC50:17.52 μM)，MMP-13 (IC50:0.27 μM)。

CAS号

29741-09-1

分子式

C21H18O11

主要靶点

MMP

仅限科研使用

Cat No : CM04105

Print datasheet

Synonyms

Apigenin 7-O-glucuronide|芹菜素-7-葡萄糖醛酸

验证数据展示

  • CAS No.: 29741-09-1

    Apigenin-7-glucuronide
    CAS#: 29741-09-1

产品信息

Apigenin-7-glucuronide possesses multiple activities, including antioxidant, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit MMP activities (IC50s: 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively).

CAS号 29741-09-1
分子式 C21H18O11
主要靶点 MMP
主要通路 蛋白酶体
分子量 446.36
纯度 97.42%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Apigenin 7-O-glucuronide|芹菜素-7-葡萄糖醛酸

靶点活性

MMP-13:0.27 μM|MMP-9:17.52 μM|MMP-8:22.39 μM|MMP-3:12.87 μM

体内活性

Apigenin-7-O-β-D-glucuronide (AG) suppressed the release of nitric oxide (NO), prostaglandin E2 (PGE2), and tumour necrosis factor-α (TNF-α) in LPS-stimulated RAW 264.7 macrophages in a dose-dependent manner without affecting cell viability. Additionally, AG suppressed LPS-induced mRNA expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and TNF-α. AG treatment decreased the translocation of c-Jun into the nucleus and decreased activator protein-1 (AP-1)-mediated luciferase activity through the inhibition of both p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) phosphorylation [2].

溶解度

DMSO:50 mg/mL (112.02 mM)

参考文献

1.Crascì L, et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83(11):901-911.
2.Hu W, et al. Apigenin-7-O-β-D-glucuronide inhibits LPS-induced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and protects mice against endotoxin shock. Food Funct. 2016 Feb;7(2):1002-13.

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