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Asoxime dichloride

Asoxime dichloride (Tert-Butyl2-(2-hydroxyethyl)-1-pyrrolidinecarboxylate) 是乙酰胆碱受体 (AChRs) 拮抗剂，包括烟碱受体，α7 乙酰胆碱受体。Asoxime dichloride 参与调节免疫应答。Asoxime dichloride 可作为抗原使用，改善神经系统的免疫效果。

CAS号

34433-31-3

分子式

C14H16Cl2N4O3

主要靶点

AChR

仅限科研使用

Cat No : CM11855

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Synonyms

Asoxime (dichloride)|Tert-Butyl2-(2-hydroxyethyl)-1-pyrrolidinecarboxylate|HI-6

验证数据展示

  • CAS No.: 34433-31-3

    Asoxime dichloride
    CAS#: 34433-31-3

产品信息

Asoxime dichloride is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system. Asoxime dichloride involves in modulating immunity response.

CAS号 34433-31-3
分子式 C14H16Cl2N4O3
主要靶点 AChR
主要通路 神经科学
分子量 359.21
纯度 99.86%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Asoxime (dichloride)|Tert-Butyl2-(2-hydroxyethyl)-1-pyrrolidinecarboxylate|HI-6

体内活性

A combination of HI-6 and keyhole limpet hemocyanin (KLH) produces a vaccination of almost the same efficacy as that for Freund's complete adjuvant[1]. Asoxime dichloride (intramuscular injection into the rear limb; 2% and 0.2% of median lethal dose 15.6 and 1.56 mg/kg; 21 or 65 days) significantly improved vaccination efficacy as a dose-dependent manner when KLH is 1 mg/kg[1].

溶解度

H2O:10 mg/mL (27.8 mM)

参考文献

1.Pohanka M, et al. HI-6 modulates immunization efficacy in a BALB/c mouse model.Environ Toxicol Pharmacol. 2013 Nov;36(3):801-6.

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