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Auraptene

Auraptene 是一种丰富的天然香叶氧基香豆素。它能够抑制基质金属蛋白酶 2 以及关键炎症因子，包括 IL-6，IL-8 和趋化因子 (C-C 基序) 配体-5 (CCL5）的分泌。

CAS号

495-02-3

分子式

C19H22O3

主要靶点

BACE|MMP

仅限科研使用

Cat No : CM03518

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Synonyms

橙皮油内酯|橙皮油素|7-geranyloxycoumarin

验证数据展示

  • CAS No.: 495-02-3

    Auraptene
    CAS#: 495-02-3

产品信息

Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis.1 When examined for its potential use in Alzheimer's disease treatment, auraptene was shown to inhibit β-secretase (BACE1) activity with an IC50 value of 345.1 μM.

CAS号 495-02-3
分子式 C19H22O3
主要靶点 BACE|MMP
主要通路 神经科学|蛋白酶体
分子量 298.4
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 橙皮油内酯|橙皮油素|7-geranyloxycoumarin

靶点活性

BACE1:345.1 μM.

溶解度

DMSO:>20 mg/mL

参考文献

1.Murakami, A.,Nakamura, Y.,Tanaka, T., et al. Suppression by citrus auraptene of phorbol ester- and endotoxin-induced inflammatory responses: Role of attenuation of leukocyte activation. Carcinogenesis 21(10), 1843-1850 (2000).
2.Krishnan, P.,Yan, K.J.,Windler, D.,et al.Citrus auraptene suppresses cyclin D1 and significantly delays N-methyl nitrosourea induced mammary carcinogenesis in female Sprague-Dawley rats.BMC Cancer9,(2009).
3.Takeda, K.,Utsunomiya, H.,Kakiuchi, S.,et al. Citrus auraptene reduces Helicobacter pylori colonization of glandular stomach lesions in Mongolian gerbils.J.Oleo Sci.56(5),253-260(2007).
4.Furukawa, Y.,Watanabe, S.,Okuyama, S., et al. Neurotrophic effect of Citrus auraptene: Neuritogenic activity in PC12 cells.International Journal of Molecular Sciences 13,5338-5347(2012).
5.Sahebkar, A.Citrus auraptene: A potential multifunctional therapeutic agent for nonalcoholic fatty liver disease.Ann.Hepatol.10(4),575-577(2011).

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