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B7-H6 Recombinant antibody, PBS Only

B7-H6 Recombinant Antibody for IF/ICC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, ELISA

Conjugate

Unconjugated

CloneNo.

240808B2

Cat no : 83908-4-PBS

Print datasheet

Synonyms

B7H6, NCR3LG1, Natural cytotoxicity triggering receptor 3 ligand 1, B7 homolog 6, B7 H6

验证数据展示

  • IF Staining of Raji using 83908-4-RR (same clone as 83908-4-PBS)

    IF Staining of Raji using 83908-4-RR (same clone as 83908-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed Raji cells using B7H6 antibody (83908-4-RR, Clone: 240808B2 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 83908-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83908-4-RR

    Affinity and Kinetic Characterization of 83908-4-RR

    Biolayer interferometry (BLl) kinetic assays of 83908-4-RR against Human B7H6 were performed. The affinity constant is below 1 pM.

产品信息

83908-4-PBS targets B7-H6 in IF/ICC, ELISA applications and shows reactivity with human samples.

Tested Applications IF/ICC, ELISA Application Description
Tested Reactivity human
Immunogen Recombinant protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name hypothetical protein DKFZp686O24166
Synonyms B7H6, NCR3LG1, Natural cytotoxicity triggering receptor 3 ligand 1, B7 homolog 6, B7 H6
Calculated Molecular Weight51 kDa
Observed Molecular Weight75-80 kDa
GenBank Accession NumberBC136800
Gene Symbol B7H6
Gene ID (NCBI) 374383
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ68D85
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

B7-H6, also known as NCR3LG1, is a member of the B7 family of immunoreceptors. It is a 454-aa-long type I transmembrane protein consisting of an extracellular region, a transmembrane segment, and a cytoplasmic domain which contains an immunoreceptor tyrosine-based inhibitory motif (ITIM), an SH2-binding domain, and an SH3-binding motif. B7-H6 triggers NKp30-mediated activation of human NK cells (PMID: 19528259). It has been reported that B7H6 is expressed in various types of tumor cells and plays a prominent role in natural killer cell immunosurveillance (PMID: 35697295). The apparent molecular weight of B7-H6 is larger than the calculated molecular weight of 51 kDa due to glycosylation (PMID: 19528259).