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验证数据展示

  • WB analysis using 66661-1-Ig (same clone as 66661-1-PBS)

    WB analysis using 66661-1-Ig (same clone as 66661-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66661-1-Ig (BAG6 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated Lamin B1 Monoclonal antibody (HRP-66095) as loading control. This data was developed using the same antibody clone with 66661-1-PBS in a different storage buffer formulation.

  • WB analysis of HEK-293 using 66661-1-Ig (same clone as 66661-1-PBS)

    WB analysis of HEK-293 using 66661-1-Ig (same clone as 66661-1-PBS)

    WB result of BAG6 antibody (66661-1-Ig; 1:4000; incubated at room temperature for 1.5 hours) with sh-Control and sh-BAG6 transfected HEK-293 cells. This data was developed using the same antibody clone with 66661-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 66661-1-Ig (same clone as 66661-1-PBS)

    IHC staining of human breast cancer using 66661-1-Ig (same clone as 66661-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66661-1-Ig (BAG6 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66661-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 66661-1-Ig (same clone as 66661-1-PBS)

    IHC staining of human breast cancer using 66661-1-Ig (same clone as 66661-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66661-1-Ig (BAG6 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66661-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

BAG6 Monoclonal antibody, PBS Only

BAG6 Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 66661-1-PBS

产品说明书

CloneNo. 1B8D3

宿主/亚型

Mouse / IgG1

种属反应性

Human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

BAG 6, BAG6, BAT3, D6S52E, G3, HLA B associated transcript 3, Protein G3

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

66661-1-PBS targets BAG6 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 Human, mouse, rat
免疫原 BAG6 fusion protein Ag24525 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 HLA-B associated transcript 3
别名 BAG 6, BAG6, BAT3, D6S52E, G3, HLA B associated transcript 3, Protein G3
计算分子量 119 kDa
观测分子量 150-160 kDa
GenBank蛋白编号BC003133
基因名称 BAT3/BAG-6
Gene ID (NCBI) 7917
RRIDAB_2858188
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP46379
储存缓冲液 PBS Only
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

BAT3 also known as Scythe or BAG6, is a nuclear protein implicated in the control of apoptosis and natural killer (NK) cell-dendritic cell (DC) interaction. BAT3 was first discovered as a member of a group of genes located within the class III region of the human major histocompatibility complex on chromosome 6, and has been extensively studied for its role in regulating apoptosis under various stress conditions such as DNA damage and endoplasmic reticulum-related stress. BAT3 has been shown to be required for p53 acetylation, which is critical for the enhancement of p53 transcriptional activity in response to DNA damage. In addition, BAT3 is involved in the regulation of development and reproduction of mammals by acting as a co-chaperone of the heat shock protein HSP70.