验证数据展示
产品信息
82961-3-RR targets BBS4 in ELISA applications and shows reactivity with Human samples.
| 经测试应用 | ELISA Application Description |
| 经测试反应性 | Human |
| 免疫原 | BBS4 fusion protein Ag3430 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | Bardet-Biedl syndrome 4 |
| 别名 | Bardet-Biedl syndrome 4 protein, Bardet Biedl syndrome 4, 230303E4 |
| 计算分子量 | 519 aa, 58 kDa |
| GenBank蛋白编号 | BC027624 |
| 基因名称 | BBS4 |
| Gene ID (NCBI) | 585 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q96RK4 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
BBS4 (Bardet-Biedl syndrome protein 4) is one of the early BBS proteins discovered, with 35 mutations reported to cause the BBS phenotype (PMID: 26762677). BBS4 undergoes localization to the centriolar satellites of centrosomes and basal body of primary cilia, where it takes part in recruiting cargo to centriolar satellites and allowing the formation of a functional centrosomal microtubule organizing center (MTOC) (PMID: 25860617). Some research has found that BBS4 expression in humans during the development of CNS and sensory organs, concerning the cardinal clinical signs of BBS (PMID: 33860840).