BCOR Polyclonal antibody

BCOR Polyclonal Antibody for WB, IP, IHC, ELISA
Cat No. 12107-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IP, IHC, ELISA and More (2)

ANOP2, BCOR, KIAA1575, MAA2, MCOPS2

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


经过测试的应用

Positive WB detected inHEK-293 cells, HeLa cells, K-562 cells
Positive IP detected inHEK-293 cells
Positive IHC detected inhuman breast cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:2000-1:10000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

12107-1-AP targets BCOR in WB, IHC, IP, CoIP, ChIP, ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IP, IHC, ELISA Application Description
文献引用应用WB, IHC, IP, CoIP, ChIP
经测试反应性 human, mouse, rat
文献引用反应性human, mouse
免疫原 BCOR fusion protein Ag2752 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 BCL6 co-repressor
别名 ANOP2, BCOR, KIAA1575, MAA2, MCOPS2
计算分子量 1703 aa, 186 kDa
观测分子量 186 kDa
GenBank蛋白编号BC009675
基因名称 BCOR
Gene ID (NCBI) 54880
RRIDAB_2290335
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ6W2J9
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

BCOR, a corepressor of BCL6, binds to transcriptional factors and specifically inhibits gene expression. BCOR plays a key role in the early embryonic development, mesenchymal stem cell function and hematopiesis. BCOR can associate with HDACs, the polycomb group protein, polycomb group Ring finger protein1/nervous system polycomb1 (PCGF1/NSPC1), histone demethylase, F-box- and leucine-rich repeat protein10(FBXL10). Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem

实验方案

Product Specific Protocols
WB protocol for BCOR antibody 12107-1-APDownload protocol
IHC protocol for BCOR antibody 12107-1-APDownload protocol
IP protocol for BCOR antibody 12107-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
WB, IHC

Nat Genet

Consistent in-frame internal tandem duplications of BCOR characterize clear cell sarcoma of the kidney.

Authors - Hitomi Ueno-Yokohata
humanWB

Blood

Epigenetic Regulation of Non-canonical Menin Targets Modulates Menin Inhibitor Response in Acute Myeloid Leukemia

Authors - Xinyue Zhou
humanWB

Nucleic Acids Res

Bimodal regulation of the PRC2 complex by USP7 underlies tumorigenesis.

Authors - Dongxue Su
mouseWB

Int J Mol Sci

BCOR Internal Tandem Duplication Expression in Neural Stem Cells Promotes Growth, Invasion, and Expression of PRC2 Targets.

Authors - Satoshi Nakata
mouseWB

Sci Rep

Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells.

Authors - Yun Yan

Cell Prolif

Secreted frizzled-related protein 2 promotes the osteo/odontogenic differentiation and paracrine potentials of stem cells from apical papilla under inflammation and hypoxia conditions.

Authors - Haoqing Yang
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