验证数据展示
产品信息
13331-1-AP targets Beta TRCP in ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 | Beta TRCP fusion protein Ag4139 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | beta-transducin repeat containing |
| 别名 | Beta TRCP, BETA TRCP,BTRC, betaTrCP, BTRC, bTrCP, bTrCP1, E3RSIkappaB, FBW1A, FBXW1, FBXW1A, FWD1 |
| 计算分子量 | 605 aa, 69 kDa |
| GenBank蛋白编号 | BC027994 |
| 基因名称 | Beta TRCP |
| Gene ID (NCBI) | 8945 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9Y297 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
BTRC, also named as BTRCP, FBW1A and FBXW1A, is an F-box family protein. It is a Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. BTRC targets many important proteins with diverse functions, such as p53, HRAS, NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and the cell cycle checkpoint protein claspin, for ubiquitin-mediated degradation. It is required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.